The objective of this study was to analyse the structure of CPP-2, and to observe the pharmacological effects of CPP-2 on lipid metabolism and oxidative stress. CPP-2, eluted as two main fractions comprised of two polysaccharides with Mw of 307 and 3.7 kDa, was mainly consisted of rhamnose, mannose, glucose and galactose in a molar ratio of 1.00:0.78:3.22:0.45. The results showed that treatment with CPP-2 could improve blood lipid levels (TC, TG, HDL-C and LDL-C), liver lipid levels (TC and TG) and antioxidant status (SOD, T-AOC, GSH-PX, MDA and LPO). In addition, the histopathological observations of mice livers and the GPT activities indicated that CPP-2 could attenuate liver cell injury. The present findings demonstrated that CPP-2 might be effective in lowering lipid and protecting against HFE-induced hyperlipidemia and non-alcoholic fatty liver.

这项研究的目的是分析CPP-2的结构，并观察CPP-2对脂质代谢和氧化应激的药理作用。CPP-2，被洗脱为两个主要馏分，由两个含有Mw的多糖组成307和3.7 kDa的摩尔比主要由鼠李糖，甘露糖，葡萄糖和半乳糖组成，摩尔比为1.00：0.78：3.22：0.45。结果表明，使用CPP-2可以改善血脂水平（TC，TG，HDL-C和LDL-C），肝血脂水平（TC和TG）和抗氧化剂状态（SOD，T-AOC，GSH-PX， MDA和LPO）。另外，小鼠肝脏的组织病理学观察和GPT活性表明CPP-2可以减轻肝细胞损伤。本研究结果表明，CPP-2可能有效降低脂质并预防HFE引起的高脂血症和非酒精性脂肪肝。