Galectin-3 is a pleiotropic protein involved in cell activation, proliferation and migration and plays a pivotal part as an inflammatory mediator in neurodegeneration. Galectin-3 is associated with microglial activation and proliferation after ischemia. Given its putative role as a dynamic fine-tuner of microglia, activation of Galectin-3 provides molecular cues in design of new immunomodulatory strategies for stroke management. This review summarizes recent evidence on the role of Galectin-3 as a mediator of immune responses in damaged brain and mechanisms employed by Galectin-3 to affect microglial function.

中文翻译：

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Galectin-3：受伤的大脑中小胶质细胞反应的介体

Galectin-3是一种参与细胞活化，增殖和迁移的多效性蛋白，在神经退行性变中起炎性介质的作用。Galectin-3与缺血后小胶质细胞的活化和增殖有关。鉴于其作为小胶质细胞的动态微调剂的推定作用，Galectin-3的激活为中风治疗新免疫调节策略的设计提供了分子线索。这篇综述总结了有关Galectin-3在受损大脑中免疫反应介质的作用以及Galectin-3影响小胶质细胞功能的机制的最新证据。