The Cu dispersed on mesoporous SBA-15 has demonstrated the regioselective CH bond C₃-cyanation of indoles by in-situ generation of CN using DMF and NH₄I in presence of O₂. Pyridine adsorbed diffuse reflectance infrared spectroscopy (DRIFTS) results revealed that surface Cu²⁺ species are acting as Lewis acid sites in the in-situ generation of cyano- group for the synthesis of indole nitriles. A direct correlation between Cu metal surface area and the indole nitrile yields are established and the dual role of copper is substantiated by N₂O titration and XPS techniques. The 10 wt%Cu/SBA-15 demonstrated superior performance when compared to Pd, Ru supported on SBA-15. The 10 wt%Cu/SBA-15 catalyst showed consistent activity and selectivity after the 4th cycle.

分散在中孔SBA-15上的Cu通过在O ₂存在下使用DMF和NH ₄ I原位生成CN证明了吲哚的区域选择性C H键C ₃氰化。吡啶吸附的漫反射红外光谱（DRIFTS）结果表明，表面铜²⁺物种在原位生成氰基的吲哚腈合成中充当路易斯酸位。建立了铜金属表面积与吲哚腈收率之间的直接关系，并且N ₂证实了铜的双重作用O滴定和XPS技术。与负载在SBA-15上的Pd，Ru相比，10 wt％Cu / SBA-15表现出优异的性能。在第四个循环后，10 wt％Cu / SBA-15催化剂显示出一致的活性和选择性。