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An insight on the influence of surface Lewis acid sites for regioselective CH bond C3-cyanation of indole using NH4I and DMF as combined cyanide source over Cu/SBA-15 catalyst
Molecular Catalysis ( IF 3.9 ) Pub Date : 2017-11-10 , DOI: 10.1016/j.mcat.2017.11.007
Venu Boosa , Vishali Bilakanti , Vijay Kumar Velisoju , Naresh Gutta , Sreedhar Inkollu , Venugopal Akula

The Cu dispersed on mesoporous SBA-15 has demonstrated the regioselective CH bond C3-cyanation of indoles by in-situ generation of CN using DMF and NH4I in presence of O2. Pyridine adsorbed diffuse reflectance infrared spectroscopy (DRIFTS) results revealed that surface Cu2+ species are acting as Lewis acid sites in the in-situ generation of cyano- group for the synthesis of indole nitriles. A direct correlation between Cu metal surface area and the indole nitrile yields are established and the dual role of copper is substantiated by N2O titration and XPS techniques. The 10 wt%Cu/SBA-15 demonstrated superior performance when compared to Pd, Ru supported on SBA-15. The 10 wt%Cu/SBA-15 catalyst showed consistent activity and selectivity after the 4th cycle.



中文翻译:

在NH 4 I和DMF作为氰化物源的Cu / SBA-15催化剂上,表面Lewis酸位对吲哚的区域选择性C H键C 3-氰化的影响的见解。

分散在中孔SBA-15上的Cu通过在O 2存在下使用DMF和NH 4 I原位生成CN证明了吲哚的区域选择性C H键C 3氰化。吡啶吸附的漫反射红外光谱(DRIFTS)结果表明,表面铜2+物种在原位生成氰基的吲哚腈合成中充当路易斯酸位。建立了铜金属表面积与吲哚腈收率之间的直接关系,并且N 2证实了铜的双重作用O滴定和XPS技术。与负载在SBA-15上的Pd,Ru相比,10 wt%Cu / SBA-15表现出优异的性能。在第四个循环后,10 wt%Cu / SBA-15催化剂显示出一致的活性和选择性。

更新日期:2017-11-10
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