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EGFR-Targeted Magnetic Nanovectors Recognize, in Vivo, Head and Neck Squamous Cells Carcinoma-Derived Tumors
ACS Medicinal Chemistry Letters ( IF 3.5 ) Pub Date : 2017-11-10 00:00:00 , DOI: 10.1021/acsmedchemlett.7b00278 David Colecchia 1 , Elena Nicolato , Costanza Ravagli 2 , Paola Faraoni 3 , Angela Strambi 1 , Matteo Rossi 1 , Saer Doumett 2 , Elisa Mosconi , Erica Locatelli 4 , Mauro Comes Franchini 4 , Manuela Balzi 3 , Giovanni Baldi 2 , Pasquina Marzola , Mario Chiariello 1
ACS Medicinal Chemistry Letters ( IF 3.5 ) Pub Date : 2017-11-10 00:00:00 , DOI: 10.1021/acsmedchemlett.7b00278 David Colecchia 1 , Elena Nicolato , Costanza Ravagli 2 , Paola Faraoni 3 , Angela Strambi 1 , Matteo Rossi 1 , Saer Doumett 2 , Elisa Mosconi , Erica Locatelli 4 , Mauro Comes Franchini 4 , Manuela Balzi 3 , Giovanni Baldi 2 , Pasquina Marzola , Mario Chiariello 1
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Head and neck squamous cell carcinomas (HNSCC) are a diverse group of tumors with high morbidity and mortality that have remained mostly unchanged over the past decades. The epidermal growth factor receptor (EGFR) is often overexpressed and activated in these tumors and strongly contributes to their pathogenesis. Still, EGFR-targeted therapies such as monoclonal antibodies and kinase inhibitors have demonstrated only limited improvements in the clinical outcome of this disease. Here, we take advantage of the extraordinary affinity of EGF for its cognate receptor to specifically target magnetite-containing nanoparticles to HNSCC cells and mediate, in vitro, their cellular upload. On the basis of this, we show efficient accumulation, in vivo, of such nanoparticles in subcutaneous xenograft tumor tissues in sufficient amounts to be able to mediate visualization by magnetic resonance imaging. Overall, our EGF-coated nanosystem may warrant, in the near future, novel and very efficient theranostic approaches to HNSCC.
中文翻译：
EGFR靶向的磁性纳米载体在体内识别头颈部鳞状细胞癌衍生的肿瘤。
头颈部鳞状细胞癌（HNSCC）是一组发病率高和死亡率高的肿瘤，在过去的几十年中几乎保持不变。表皮生长因子受体（EGFR）通常在这些肿瘤中过表达和激活，并强烈促进其发病机理。尽管如此，针对EGFR的疗法（例如单克隆抗体和激酶抑制剂）在该疾病的临床结果中仅显示出有限的改善。在这里，我们利用EGF与其同源受体的超强亲和力，将含磁铁矿的纳米颗粒特异性靶向HNSCC细胞，并在体外介导其细胞上载。在此基础上，我们展示了体内有效的积累皮下异种移植肿瘤组织中的此类纳米颗粒的量足以通过磁共振成像介导可视化。总体而言，我们的EGF涂层纳米系统可能会在不久的将来为HNSCC带来新颖且非常有效的治疗方法。
更新日期：2017-11-10
中文翻译：
EGFR靶向的磁性纳米载体在体内识别头颈部鳞状细胞癌衍生的肿瘤。
头颈部鳞状细胞癌（HNSCC）是一组发病率高和死亡率高的肿瘤，在过去的几十年中几乎保持不变。表皮生长因子受体（EGFR）通常在这些肿瘤中过表达和激活，并强烈促进其发病机理。尽管如此，针对EGFR的疗法（例如单克隆抗体和激酶抑制剂）在该疾病的临床结果中仅显示出有限的改善。在这里，我们利用EGF与其同源受体的超强亲和力，将含磁铁矿的纳米颗粒特异性靶向HNSCC细胞，并在体外介导其细胞上载。在此基础上，我们展示了体内有效的积累皮下异种移植肿瘤组织中的此类纳米颗粒的量足以通过磁共振成像介导可视化。总体而言，我们的EGF涂层纳米系统可能会在不久的将来为HNSCC带来新颖且非常有效的治疗方法。
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