Achieving Molecular Complexity via Stereoselective Multiple Domino Reactions Promoted by a Secondary Amine Organocatalyst,Accounts of Chemical Research

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Achieving Molecular Complexity via Stereoselective Multiple Domino Reactions Promoted by a Secondary Amine Organocatalyst
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2017-11-10 00:00:00 , DOI: 10.1021/acs.accounts.7b00406
Pankaj Chauhan ₁ , Suruchi Mahajan ₁ , Dieter Enders ₁

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In the last two decades, organocatalysis has emerged as an intensively investigated and rapidly growing area of research facilitating many known and many new transformations to provide efficient novel entries to complex molecules of high stereochemical purity. The organocatalysts have not only shown their efficiency for catalyzing the reactions in which one bond is formed, but they have also been effectively exploited in various versions of one-pot reactions. Domino reactions are one of the most important classes of one-pot reactions, where the target structure can be obtained in one pot without changing any reaction conditions while each reaction occurs as a consequence of the intermediates generated in previous steps. Owing to the synthetic importance and operational advantages associated with the use of organocatalysts and the development of domino reactions, various asymmetric transformations leading to a complex structure of choice have been explored. The early era of organocatalysis exhibits a limited growth in the development of asymmetric domino reactions with special emphasis on two reactions occurring one after the other.

中文翻译：

通过由仲胺有机催化剂促进的立体选择性多米诺反应实现分子复杂性

在过去的二十年中，有机催化已经成为一个经过深入研究并且发展迅速的研究领域，它促进了许多已知的和许多新的转化，从而为高立体化学纯度的复杂分子提供了有效的新颖入口。有机催化剂不仅显示出催化形成一个键的反应的效率，而且还被有效地用于各种形式的一锅法反应中。多米诺反应是一锅法最重要的一类，其中一锅即可获得目标结构，而无需改变任何反应条件，而每个反应都是由于先前步骤中产生的中间体而发生的。由于与有机催化剂的使用和多米诺反应的发展相关的综合重要性和操作优势，已经探索了导致选择复杂结构的各种不对称转化。有机催化的早期时代在不对称多米诺反应的发展中显示出有限的增长，特别着重于一个接一个发生的两个反应。

更新日期：2017-11-10

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