A novel Konjac glucomannan/silver nanoparticle (KGM/AgNP) composite sponge was successfully prepared via a simple 2-step method for biomedical applications as wound-healing materials. First, AgNPs were prepared with green deoxidizer egg white. Then, KGM powder was added to the AgNP solution and stirred vigorously, and the composite sponge was obtained by freeze-drying. The KGM/AgNP composite sponge showed excellent water absorption and water retention, and considerable mechanical properties. KGM/AgNP composite sponges displayed good antibacterial activity against test microorganisms. In vitro cytocompatibility testing showed that L929 cells could survive well in the presence of KGM/AgNPs, indicating that KGM/AgNPs have good cytocompatibility. Animal models showed that the KGM/AgNP composite sponges effectively accelerated wound healing, and histological findings showed that they promoted fibroblast growth and accelerated epithelialization. The experimental results showed that KGM/AgNP composite sponges have great potential in promoting wound healing.

通过简单的两步法成功地制备了一种新型魔芋葡甘露聚糖/银纳米颗粒（KGM / AgNP）复合海绵，用于生物医学应用作为伤口愈合材料。首先，用绿色的脱氧蛋清制备AgNP。然后，将KGM粉末添加到AgNP溶液中并剧烈搅拌，并且通过冷冻干燥获得复合海绵。KGM / AgNP复合海绵具有出色的吸水率和保水性，并具有可观的机械性能。KGM / AgNP复合海绵对测试微生物显示出良好的抗菌活性。体外细胞相容性测试表明，在存在KGM / AgNPs的情况下，L929细胞可以很好地存活，这表明KGM / AgNPs具有良好的细胞相容性。动物模型显示，KGM / AgNP复合海绵可有效加速伤口愈合，组织学发现表明它们促进成纤维细胞生长并加速上皮形成。实验结果表明，KGM / AgNP复合海绵具有促进伤口愈合的巨大潜力。