Kinetics of photodegradation of novel oral anticoagulants dabigatran, rivaroxaban, and apixaban were studied under simulated solar light irradiation in purified, mineral, and river waters. Dabigatran and rivaroxaban underwent direct photolysis with polychromatic quantum yields of 2.2 × 10⁻⁴ and 4.4 × 10⁻², respectively. The direct photodegradation of apixaban was not observed after 19 h of irradiation. Kinetics of degradation of rivaroxaban was not impacted by the nature of the aqueous matrix while photosensitization from nitrate ions was observed for dabigatran and apixaban dissolved in a mineral water. The photosensitized reactions were limited in the tested river water (Isle River, Périgueux, France) certainly due to the hydroxyl radical scavenging effect of the dissolved organic matter. The study of photoproduct structures allowed to identify two compounds for dabigatran. One of them is the 4-aminobenzamidine while the second one is a cyclization product. In the case of rivaroxaban, as studied by very high field NMR, only one photoproduct was observed i.e. a photoisomer. Finally, seven photoproducts were clearly identified from the degradation of apixaban under simulated solar light.

在模拟的太阳光照射下，在纯净水，矿泉水和河水中研究了新型口服抗凝剂达比加群，利伐沙班和阿哌沙班的光降解动力学。达比加群和利伐沙班进行了直接光解，其多色量子产率分别为2.2×10 ^-4和4.4×10 ^-2， 分别。照射19小时后未观察到阿哌沙班的直接光降解。利伐沙班的降解动力学不受水性基质性质的影响，而溶解在矿泉水中的达比加群和阿哌沙班观察到硝酸根离子的光敏作用。当然，由于溶解的有机物的羟基自由基清除作用，光敏反应在测试的河水中（Isle River，Périgueux，法国）受到限制。通过对光产物结构的研究，可以鉴定出达比加群的两种化合物。其中之一是4-氨基苯甲m，而第二个是环化产物。在利伐沙班的情况下，如通过超高场NMR研究，仅观察到一种光产物，即光异构体。最后，从模拟太阳光下阿哌沙班的降解中清楚地鉴定出七个光产物。