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Hidden Secrets of Sigma54 Promoters Revealed
Trends in Biochemical Sciences ( IF 11.6 ) Pub Date : 2017-11-07 , DOI: 10.1016/j.tibs.2017.10.005
Nan Hao , Keith E. Shearwin

Bacterial sigma54 (σ54) promoters are the DNA-binding motif for σ54-containing RNA polymerase (RNAP) holoenzymes. A recent study using a combination of synthetic oligonucleotide library screening, biochemical characterization, and bioinformatics has uncovered a new and unexpected role for σ54 promoters, encoding a form of bacterial ‘insulator sequence’ to dampen unwanted translation.



中文翻译:

揭示了Sigma54启动子的隐藏秘密

细菌sigma54(σ 54)启动子可用于σ的DNA结合基序54含RNA聚合酶(RNAP)全酶。使用合成寡核苷酸文库筛选,生化特征和生物信息学的结合最近的研究已经揭示了σ新的和意想不到的作用54个推动者,编码细菌“绝缘体”序列的形式来抑制不必要的翻译。

更新日期:2017-11-07
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