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Cracking the Chaperone Code: Cellular Roles for Hsp70 Phosphorylation
Trends in Biochemical Sciences ( IF 11.6 ) Pub Date : 2017-11-05 , DOI: 10.1016/j.tibs.2017.10.002
Nitika , Andrew W. Truman

Heat shock protein 70 (Hsp70) is a molecular chaperone required for protein folding, cell viability, and cancer cell proliferation. Recent studies suggest that Hsp70 phosphorylation regulates important cellular processes, such as cell cycle progression, apoptosis, protein degradation, and resistance to anticancer therapeutics.



中文翻译:

破解伴侣代码:Hsp70磷酸化的细胞作用。

热激蛋白70(Hsp70)是蛋白质折叠,细胞活力和癌细胞增殖所需的分子伴侣。最近的研究表明,Hsp70磷酸化调节重要的细胞过程,例如细胞周期进程,细胞凋亡,蛋白质降解以及对抗癌疗法的抵抗力。

更新日期:2017-11-05
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