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Mesoporous silica nanoparticles: a smart nanosystem for management of breast cancer
Drug Discovery Today ( IF 6.5 ) Pub Date : 2017-11-08 , DOI: 10.1016/j.drudis.2017.10.022
Neelam Poonia , Viney Lather , Deepti Pandita

Breast cancer is the second-leading cause of death in women worldwide owing to aggressive metastasis, lack of early diagnosis and poor access to treatment amenities. During the past decade, mesoporous silica nanoparticles (MSNs) have gained ground for the delivery of a wide variety of chemotherapeutic and bioimaging agents owing to their unique characteristics and straightforward fabrication methods. Present research studies based on MSNs have provided various potential insights in their applicability in breast cancer treatment by improving solubility and stability and decreasing the adverse effects of current treatment regimens. This review focuses on the applicability of this novel modality in the management of breast cancer.



中文翻译:

介孔二氧化硅纳米颗粒:用于治疗乳腺癌的智能纳米系统

由于侵袭性转移,缺乏早期诊断和难以获得治疗设施,乳腺癌是全世界女性的第二大死亡原因。在过去的十年中,中孔二氧化硅纳米粒子(MSN)由于其独特的特性和简单的制造方法,已为递送多种化学治疗剂和生物成像剂赢得了发展。目前,基于MSN的研究通过提高溶解度和稳定性并减少当前治疗方案的不良反应,提供了各种潜在的见解,以探讨其在乳腺癌治疗中的适用性。这篇综述集中于这种新颖的方式在乳腺癌管理中的适用性。

更新日期:2017-11-08
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