Abstract

An efficient and simple method for the synthesis of pyrazolo[3,4-a]acridine and pyrazolo[4,3-a]acridine derivatives directly form nitro compounds by in situ reduction and cyclization reaction under Fe/H₂O medium is reported. Compared to amino compounds, nitro compounds are more stable and easier to obtain. In addition, because iron is a nontoxic, inexpensive, and environmentally friendly reductant, this method is especially suitable for organic synthesis. The other advantages of this process are cheap raw materials, less pollution, and wide substrate range.

An efficient and simple method for the synthesis of pyrazolo[3,4-a]acridine and pyrazolo[4,3-a]acridine derivatives directly form nitro compounds by in situ reduction and cyclization reaction under Fe/H₂O medium is reported. Compared to amino compounds, nitro compounds are more stable and easier to obtain. In addition, because iron is a nontoxic, inexpensive, and environmentally friendly reductant, this method is especially suitable for organic synthesis. The other advantages of this process are cheap raw materials, less pollution, and wide substrate range.

中文翻译：

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高效的Fe / H2O介质原位还原和环化反应合成吡唑并[3,4-a] ac啶-10-酮和吡唑并[4,3-a] ac啶-10-酮衍生物

摘要

报道了一种在Fe / H ₂ O介质中原位还原和环化反应合成吡唑并[3,4- a ] ac啶和吡唑并[4,3- a ]]啶衍生物直接形成硝基化合物的有效简便方法。与氨基化合物相比，硝基化合物更稳定，更容易获得。此外，由于铁是一种无毒，廉价且环保的还原剂，因此该方法特别适用于有机合成。该方法的其他优点是原料便宜，污染少，基材范围广。

报道了一种在Fe / H ₂ O介质中原位还原和环化反应合成吡唑并[3,4- a ] ac啶和吡唑并[4,3- a ]]啶衍生物直接形成硝基化合物的有效简便方法。与氨基化合物相比，硝基化合物更稳定，更容易获得。此外，由于铁是一种无毒，廉价且环保的还原剂，因此该方法特别适用于有机合成。该方法的其他优点是原料便宜，污染少，基材范围广。