Abstract

Anisomycin shows potent biological activity and it has attracted much attention since its isolation in 1954, with around 13 total syntheses and 20 formal syntheses, and also two reports concerning analogues of anisomycin, reported to date. The present review highlights all of these synthetic approaches (around 35) to the total or formal synthesis of anisomycin along with its isomers and analogues.

1 Introduction

2 Isolation and Therapeutic Importance

3 Total Synthesis of (+)-, (–)-, and (±)-Anisomycins and Their Analogues

4 Formal Synthesis of (+)- and (–)-Anisomycins and Their Analogues

5 Conclusion

Anisomycin shows potent biological activity and it has attracted much attention since its isolation in 1954, with around 13 total syntheses and 20 formal syntheses, and also two reports concerning analogues of anisomycin, reported to date. The present review highlights all of these synthetic approaches (around 35) to the total or formal synthesis of anisomycin along with its isomers and analogues.

1 Introduction

2 Isolation and Therapeutic Importance

3 Total Synthesis of (+)-, (–)-, and (±)-Anisomycins and Their Analogues

4 Formal Synthesis of (+)- and (–)-Anisomycins and Their Analogues

5 Conclusion

中文翻译：

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（+）-和（-）-茴香霉素及其类似物的合成研究

摘要

自1954年分离以来，茴香霉素显示出强大的生物学活性，并引起了广泛的关注，迄今已报道了约13种总合成物和20种正式合成物，还有两项有关茴香霉素类似物的报道。本综述重点介绍了茴香霉素及其异构体和类似物的全部或正式合成的所有这些合成方法（约35种）。

1引言

2隔离和治疗重要性

3（+）-，（-）-和（±）-阿霉素的全合成及其类似物

4（+）-和（-）-茴香霉素及其类似物的形式合成

5结论

自1954年分离以来，茴香霉素显示出强大的生物学活性，并引起了广泛的关注，迄今已报道了约13种总合成物和20种正式合成物，还有两项有关茴香霉素类似物的报道。本综述重点介绍了茴香霉素及其异构体和类似物的全部或正式合成的所有这些合成方法（约35种）。

1引言

2隔离和治疗重要性

3（+）-，（-）-和（±）-阿霉素的全合成及其类似物

4（+）-和（-）-茴香霉素及其类似物的形式合成

5结论