Abstract

Benzimidazole belongs to the top five most commonly used five-membered aromatic nitrogen heterocycles among U.S. FDA approved pharmaceuticals. Over the last few years, a large number of improved synthetic strategies have been developed to construct the benz­imidazole molecular framework under environmentally benign conditions. This review focuses on the use of primary amines as readily available substrates for the synthesis of benzimidazole derivatives through different types of oxidative cross-coupling reactions.

1 Introduction

2 Catalyst-Free Oxidative Coupling of Primary Amines

3 Catalytic Oxidative Coupling of Primary Amines

3.1 Metal-Catalyzed Reactions

3.2 Metal-Free Catalyzed Reactions

3.3 Bioinspired Catalyzed Reactions

4 Conclusion

Benzimidazole belongs to the top five most commonly used five-membered aromatic nitrogen heterocycles among U.S. FDA approved pharmaceuticals. Over the last few years, a large number of improved synthetic strategies have been developed to construct the benz­imidazole molecular framework under environmentally benign conditions. This review focuses on the use of primary amines as readily available substrates for the synthesis of benzimidazole derivatives through different types of oxidative cross-coupling reactions.

1 Introduction

2 Catalyst-Free Oxidative Coupling of Primary Amines

3 Catalytic Oxidative Coupling of Primary Amines

3.1 Metal-Catalyzed Reactions

3.2 Metal-Free Catalyzed Reactions

3.3 Bioinspired Catalyzed Reactions

4 Conclusion

中文翻译：

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伯胺氧化偶联合成苯并咪唑衍生物的最新进展

摘要

在美国FDA批准的药物中，苯并咪唑属于前五种最常用的五元芳族氮杂环。在过去的几年中，已经开发出许多改进的合成策略以在环境良好的条件下构建苯并咪唑分子骨架。这篇综述集中在使用伯胺作为通过不同类型的氧化交叉偶联反应合成苯并咪唑衍生物的容易获得的底物。

1引言

2伯胺的无催化剂氧化偶联

3伯胺的催化氧化偶联

3.1金属催化反应

3.2无金属催化反应

3.3生物启发的催化反应

4。结论

在美国FDA批准的药物中，苯并咪唑属于前五种最常用的五元芳族氮杂环。在过去的几年中，已经开发出许多改进的合成策略以在环境良好的条件下构建苯并咪唑分子骨架。这篇综述集中在使用伯胺作为通过不同类型的氧化交叉偶联反应合成苯并咪唑衍生物的容易获得的底物。

1引言

2伯胺的无催化剂氧化偶联

3伯胺的催化氧化偶联

3.1金属催化反应

3.2无金属催化反应

3.3生物启发的催化反应

4。结论