In this paper, we constructed a novel label-free analytical strategy for highly sensitive and selective detection of nitrofurantoin (NFT) based on adenosine-stabilized copper nanoclusters (CuNCs) as nanoprobes. It was found that NFT caused a rapid decrease in the photoluminescence intensity of CuNCs. The photoluminescence quenching was likely attributed to the inner filter effect between NFT and CuNCs. The CuNCs exhibited a wide linear range of 0.05–4.0 μM with the detection limit of 30 nM (7.1 ng mL⁻¹) for detection of NFT. And it was successfully applied for NFT detection in lake water samples.

中文翻译：

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使用腺苷稳定的铜纳米团簇作为纳米探针的湖水样品中呋喃妥因检测的无标记光致发光测定

在本文中，我们构建了一种新型的无标记分析策略，该方法基于腺苷稳定的铜纳米簇（CuNCs）作为纳米探针，用于高灵敏度和选择性地检测呋喃妥因（NFT）。发现NFT引起CuNCs的光致发光强度快速降低。光致发光猝灭很可能归因于NFT和CuNC之间的内部滤镜效应。CuNCs表现出0.05-4.0μM的宽线性范围，用于检测NFT的检测限为30 nM（7.1 ng mL ^-1）。它已成功地应用于湖水中样品的NFT检测。