High salinity and a relatively high pH are two factors characterizing the marine water environment, which is one of the main final reservoirs receiving pharmaceutical residues. The same factors have an undeniable impact on the extraction efficiency and kinetics of uptakes of polar analytes from water by sorbent-based passive sampling techniques. Recently, we presented a novel passive sampling technique, in which ionic liquids are applied as receiving phases for pharmaceutical monitoring in water (the Passive Sampling with Ionic Liquids technique). In this paper we test the impact of salinity and pH on the PASSIL calibration (sampling rate determination) and the extraction efficiencies of sulfonamides, beta-blockers and nonsteroidal anti-inflammatory drugs selected as model contaminants. Trihexyl(tetradecyl)phosphonium dicyanamide ([P666-14][N(CN)₂]) was taken as the stable liquid receiving phase. It selectively extracted neutral and negatively charged analytes from donor solutions of different pH (1, 3, 7 and 9). The presence of salt (7, 20 and 35 PSU) decreased the efficiency (by 5–65%) and R_s (by 0.017 L day⁻¹ to 0.574 L day⁻¹) of PASSIL for all target compounds. The general conclusion is that salinity and pH have a significant impact on the calibration of passive dosimeters for ionizable compounds, both for the new PASSIL technique and standard POCIS techniques.

高盐度和相对较高的pH是表征海水环境的两个因素，海水是接收药物残留物的主要最终储层​​之一。相同的因素对于通过基于吸附剂的被动采样技术从水中提取极性分析物的提取效率和动力学具有不可否认的影响。最近，我们提出了一种新颖的无源采样技术，其中离子液体被用作接收阶段，用于水中的药物监测（带离子​​液体的无源采样技术）。在本文中，我们测试了盐度和pH对PASSIL校准（采样率测定）的影响以及作为模型污染物的磺酰胺，β受体阻滞剂和非甾体抗炎药的提取效率。三己基（十四烷基）phosph双氰胺（[P666-14] [N（CN）_将2 ]）作为稳定的液体接收阶段。它从不同pH（1、3、7和9）的供体溶液中选择性提取中性和带负电荷的分析物。盐（7、20和35 PSU）的存在降低了所有目标化合物的PASSIL的效率（降低了5–65％）和R _s（降低了0.017 L天^-1至0.574 L天^-1）。总的结论是，无论是新的PASSIL技术还是标准的POCIS技术，盐度和pH值都对可电离化合物的被动剂量计的校准产生重大影响。