Comparative study of siderophore biosynthesis pathway in pathogens provides potential targets for antibiotics and host drug delivery as a part of computationally feasible microbial therapy. Iron acquisition using siderophore models is an essential and well established model in all microorganisms and microbial infections a known to cause great havoc to both plant and animal. Rapid development of antibiotic resistance in bacterial as well as fungal pathogens has drawn us at a verge where one has to get rid of the traditional way of obstructing pathogen using single or multiple antibiotic/chemical inhibitors or drugs. ‘Trojan horse’ strategy is an answer to this imperative call where antibiotic are by far sneaked into the pathogenic cell via the siderophore receptors at cell and outer membrane. This antibiotic once gets inside, generates a ‘black hole’ scenario within the opportunistic pathogens via iron scarcity. For pathogens whose siderophore are not compatible to smuggle drug due to their complex conformation and stiff valence bonds, there is another approach. By means of the siderophore biosynthesis pathways, potential targets for inhibition of these siderophores in pathogenic bacteria could be achieved and thus control pathogenic virulence. Method to design artificial exogenous siderophores for pathogens that would compete and succeed the battle of intake is also covered with this review. These manipulated siderophore would enter pathogenic cell like any other siderophore but will not disperse iron due to which iron inadequacy and hence pathogens control be accomplished. The aim of this review is to offer strategies to overcome the microbial infections/pathogens using siderophore.

病原体中铁载体生物合成途径的比较研究为抗生素和宿主药物的输送提供了潜在的目标，这是计算上可行的微生物治疗的一部分。使用铁载体模型进行铁捕获是所有微生物和微生物感染中必不可少的且已建立的模型，已知该微生物会对植物和动物造成巨大破坏。细菌和真菌病原体中抗生素耐药性的迅速发展使我们濒临灭绝，人们不得不摆脱使用单一或多种抗生素/化学抑制剂或药物阻塞病原体的传统方式。“特洛伊木马”策略是对这一当务之急的回答，在该命令中，抗生素通过细胞和外膜的铁载体受体潜入病原细胞。这种抗生素一旦进入，通过铁缺乏在机会病原体中产生“黑洞”情况。对于由于其复杂的构型和刚性价键而铁载体与走私药物不相容的病原体，还有另一种方法。通过铁载体的生物合成途径，可以实现在致病细菌中抑制这些铁载体的潜在靶标，从而控制致病性毒力。这篇综述还涵盖了为病原体设计人工外源铁载体的方法，这些病原菌会竞争并成功地完成摄入战。这些操纵的铁载体将像任何其他铁载体一样进入病原细胞，但不会分散铁，因为铁不足，因此病原体控制得以实现。