Poorly water-soluble drugs are a significant and ongoing issue for the pharmaceutical industry. An overview of recent developments for the preparation of spray-dried delivery systems is presented. Examples include amorphous solid dispersions, spray dried dispersions, microparticles, nanoparticles, surfactant systems and self-emulsifying drug delivery systems. Several aspects of formulation are considered, such as pre-screening, choosing excipient(s), the effect of polymer structure on performance, formulation optimisation, ternary dispersions, fixed-dose combinations, solvent selection and component miscibility. Process optimisation techniques including nozzle selection are discussed. Comparisons are drawn with other preparation techniques such as hot melt extrusion, freeze drying, milling, electro spinning and film casting. Novel analytical and dissolution techniques for the characterization of amorphous solid dispersions are included. Progress in understanding of amorphous supersaturation or recrystallisation from solution gathered from mechanistic studies is discussed. Aspects of powder flow and compression are considered in a section on downstream processing. Overall, spray drying has a bright future due to its versatility, efficiency and the driving force of poorly soluble drugs.

水溶性差的药物对于制药工业是一个重要且持续的问题。概述了喷雾干燥输送系统制备的最新进展。实例包括无定形固体分散体，喷雾干燥的分散体，微粒，纳米颗粒，表面活性剂系统和自乳化药物递送系统。考虑了制剂的几个方面，例如预筛选，选择赋形剂，聚合物结构对性能的影响，制剂优化，三元分散体，固定剂量组合，溶剂选择和组分混溶性。讨论了包括喷嘴选择在内的工艺优化技术。与其他制备技术进行了比较，例如热熔挤出，冷冻干燥，研磨，电纺丝和薄膜流延。包括用于表征无定形固体分散体的新型分析和溶解技术。讨论了从机理研究中收集到的溶液对非晶态过饱和或重结晶的理解的进展。粉末流动和压缩方面将在下游处理部分中进行讨论。总体而言，喷雾干燥由于其多功能性，效率和难溶性药物的驱动力而具有光明的前景。