This study demonstrates the development of pH and thermosresponsive nanoparticles (NPs) composed via cholic acid, PCPP-PLA hybrid polymer integrated with indocyanine green (ICG) for site specific delivery hydrophobic drug (paclitaxel). Drug and ICG were physically encapsulated by poly (bis(carboxyphenoxy)phosphazene) (PCPP)-poly lactic acid hybrid polymer. The hybrid polymer solution showed reversible gelation behaviour at the temperature between 37 °C and 20 °C and also it showed pH dependent drug release capability at acidic pH due to the pH responsive quenching effects of PCPP-PLA. The size (150–200 nm) and morphology of drug-loaded polymeric NPs were characterized using SEM and HR-TEM. Further, the release of loaded paclitaxel (PTX) from polymer was significantly sustained over 12 days. Drug release from the nanoparticles was effectively controlled by the mechanical strength of the polymer. All of these results demonstrate that pH triggered hybrid polymeric NPs are potential carriers for tumor-targeted drug delivery and also it exhibits great strength at 37 °C.

这项研究证明了通过胆酸，PCPP-PLA杂化聚合物与吲哚菁绿（ICG）集成而成的pH和热敏性纳米颗粒（NPs）的开发，用于定点递送疏水性药物（紫杉醇）。药物和ICG由聚（双（羧基苯氧基）磷腈）（PCPP）-聚乳酸杂化聚合物物理封装。杂化聚合物溶液在37°C和20°C之间的温度下表现出可逆的胶凝行为，并且由于PCPP-PLA对pH的响应具有猝灭作用，因此在酸性pH下也显示出pH依赖的药物释放能力。使用SEM和HR-TEM表征了载药聚合物NP的大小（150–200 nm）和形态。此外，负载的紫杉醇（PTX）从聚合物中的释放持续了12天。聚合物的机械强度有效地控制了从纳米颗粒释放的药物。所有这些结果表明，pH触发的杂化聚合物NPs是潜在的靶向肿瘤药物的载体，并且在37°C时显示出很高的强度。