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Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor
Nature Immunology ( IF 27.7 ) Pub Date : 2017-10-30 , DOI: 10.1038/ni.3868 Tomasz Maj , Wei Wang , Joel Crespo , Hongjuan Zhang , Weimin Wang , Shuang Wei , Lili Zhao , Linda Vatan , Irene Shao , Wojciech Szeliga , Costas Lyssiotis , J Rebecca Liu , Ilona Kryczek , Weiping Zou
Nature Immunology ( IF 27.7 ) Pub Date : 2017-10-30 , DOI: 10.1038/ni.3868 Tomasz Maj , Wei Wang , Joel Crespo , Hongjuan Zhang , Weimin Wang , Shuang Wei , Lili Zhao , Linda Vatan , Irene Shao , Wojciech Szeliga , Costas Lyssiotis , J Rebecca Liu , Ilona Kryczek , Weiping Zou
Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor , isJats=true)
中文翻译:
氧化应激控制肿瘤中调节性T细胞凋亡和抑制活性以及PD-L1阻滞性
氧化应激控制肿瘤中调节性T细胞凋亡和抑制活性以及PD-L1阻滞性 ,isJats = true)
更新日期:2017-11-10
Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor, Published online: 30 October 2017; doi:10.1038/ni.3868
NatureArticleSnippet(type=short-summary, markup=The tumor microenvironment represents a stressful cellular environment. Zou and colleagues show that Treg cells in tumors have heightened sensitivity to apoptosis, but unexpectedly this increases their suppressive potency.
中文翻译:
氧化应激控制肿瘤中调节性T细胞凋亡和抑制活性以及PD-L1阻滞性
氧化应激控制肿瘤中调节性T细胞凋亡和抑制活性以及PD-L1阻滞性
氧化应激控制肿瘤的调节性T细胞凋亡和抑制活性以及PD-L1阻滞性,在线发表:2017年10月30日; doi:10.1038 / ni.3868
NatureArticleSnippet(type = short-summary,markup =肿瘤微环境代表应激性细胞环境。Zou及其同事表明,肿瘤中的T reg细胞对凋亡的敏感性增强,但是出乎意料的是,这增加了它们的抑制能力。