Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior

Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior, Published online: 23 October 2017; doi:10.1038/ni.3867

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Fagarasan and colleagues show that excessive activation of T cells in mice deficient in the inhibitory receptor PD-1 causes a systemic decrease in tryptophan and tyrosine, which leads to deficiency in serotonin and dopamine in the brain and behavioral changes.

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中文翻译：

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PD-1缺陷小鼠中T细胞的系统活化引起的代谢转变扰乱了脑单胺和情绪行为

PD-1缺陷小鼠中T细胞的系统活化引起的代谢转变扰乱了脑单胺和情绪行为

PD-1缺陷小鼠中T细胞的系统性激活引起的代谢转变扰乱了脑单胺和情绪行为，在线发布：2017年10月23日；doi：10.1038 / ni.3867

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Fagarasan及其同事表明，缺乏抑制性受体PD-1的小鼠中T细胞的过度活化会导致色氨酸和酪氨酸的系统性降低，从而导致大脑中5-羟色胺和多巴胺的缺乏以及行为改变。

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