Synthetic beta cells for fusion-mediated dynamic insulin secretion,Nature Chemical Biology

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Synthetic beta cells for fusion-mediated dynamic insulin secretion
Nature Chemical Biology ( IF 12.9 ) Pub Date : 2017-10-30 , DOI: 10.1038/nchembio.2511
Zhaowei Chen _{1,

2} , Jinqiang Wang _{1,

2} , Wujin Sun _{1,

2} , Edikan Archibong ₁ , Anna R Kahkoska ₃ , Xudong Zhang _{1,

2} , Yue Lu _{1,

2} , Frances S Ligler ₁ , John B Buse ₃ , Zhen Gu _{1,

2,

3}

Affiliation

Synthetic beta cells for fusion-mediated dynamic insulin secretion

Synthetic beta cells for fusion-mediated dynamic insulin secretion, Published online: 30 October 2017; doi:10.1038/nchembio.2511

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Synthetic beta cells were fabricated through 'vesicles-in-vesicle' liposomal superstructures equipped with glucose-sensing and membrane-fusion machinery, thus enabling sensing of graded glucose levels and secretion of insulin via fusion processes.

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