A Multifunctional Polymeric Periodontal Membrane with Osteogenic and Antibacterial Characteristics,Advanced Functional Materials

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A Multifunctional Polymeric Periodontal Membrane with Osteogenic and Antibacterial Characteristics
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2017-11-10 , DOI: 10.1002/adfm.201703437
Amir Nasajpour _{1,

2} , Sahar Ansari ₃ , Chiara Rinoldi _{1,

2,

4} , Afsaneh Shahrokhi Rad _{1,

2} , Tara Aghaloo ₅ , Su Ryon Shin _{1,

2,

6} , Yogendra Kumar Mishra ₇ , Rainer Adelung ₇ , Wojciech Swieszkowski ₄ , Nasim Annabi _{1,

2,

6,

8} , Ali Khademhosseini _{1,

2,

6,

9,

10} , Alireza Moshaverinia ₃ , Ali Tamayol _{1,

2,

6,

11}

Affiliation

Biomaterials Innovation Research Center; Department of Medicine; Brigham and Women's Hospital; Harvard Medical School; Boston MA 02139 USA
Harvard-MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology; Cambridge MA 02139 USA
Weintraub Center for Reconstructive Biotechnology; Division of Advanced Prosthodontics; School of Dentistry; University of California; Los Angeles CA 90095-1668 USA
Materials Design Division; Faculty of Materials Science and Engineering; Warsaw University of Technology; 141 Woloska Str. 02-507 Warsaw Poland
Division of Diagnostic and Surgical Sciences; School of Dentistry; University of California; Los Angeles CA 90095-1668 USA
Wyss Institute for Biologically Inspired Engineering; Harvard University; Boston MA 02115 USA
Functional Nanomaterials Institute for Materials Science; Kiel University; Kaiserstra. 2 D-24143 Kiel Germany
Department of Chemical Engineering; Northeastern University; Boston MA 02115-5000 USA
Center of Nanotechnology; King Abdulaziz University; Jeddah 21569 Saudi Arabia
Department of Bioindustrial Technologies; College of Animal Bioscience and Technology; Konkuk University; Seoul Republic of Korea
Department of Mechanical and Materials Engineering; University of Nebraska, Lincoln; Lincoln NE 68588 USA

Periodontitis is a prevalent chronic, destructive inflammatory disease affecting tooth‐supporting tissues in humans. Guided tissue regeneration strategies are widely utilized for periodontal tissue regeneration generally by using a periodontal membrane. The main role of these membranes is to establish a mechanical barrier that prevents the apical migration of the gingival epithelium and hence allowing the growth of periodontal ligament and bone tissue to selectively repopulate the root surface. Currently available membranes have limited bioactivity and regeneration potential. To address such challenges, an osteoconductive, antibacterial, and flexible poly(caprolactone) (PCL) composite membrane containing zinc oxide (ZnO) nanoparticles is developed. The membranes are fabricated through electrospinning of PCL and ZnO particles. The physical properties, mechanical characteristics, and in vitro degradation of the engineered membrane are studied in detail. Also, the osteoconductivity and antibacterial properties of the developed membrane are analyzed in vitro. Moreover, the functionality of the membrane is evaluated with a rat periodontal defect model. The results confirmed that the engineered membrane exerts both osteoconductive and antibacterial properties, demonstrating its great potential for periodontal tissue engineering.

中文翻译：

具有成骨和抗菌特性的多功能聚合物牙周膜

牙周炎是一种普遍的慢性破坏性炎症性疾病，会影响人体的牙齿支撑组织。通常通过使用牙周膜，引导组织再生策略被广泛用于牙周组织再生。这些膜的主要作用是建立机械屏障，以防止牙龈上皮的根尖迁移，从而允许牙周膜和骨组织的生长选择性地重新填充牙根表面。当前可用的膜具有有限的生物活性和再生潜力。为了解决这些挑战，开发了包含氧化锌（ZnO）纳米颗粒的骨传导性，抗菌性和柔性聚（己内酯）（PCL）复合膜。膜是通过电纺PCL和ZnO颗粒制成的。详细研究了工程膜的物理特性，机械特性和体外降解。而且，在体外分析了所开发的膜的骨传导性和抗菌性能。此外，用大鼠牙周缺损模型评估膜的功能。结果证实，工程膜既具有骨传导性又具有抗菌性，证明了其在牙周组织工程中的巨大潜力。

更新日期：2017-11-10

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