Artificial chromosomes are useful in making functional vectors for very large genes, studying chromosome physiology, and modeling chromosomal disorders. Shinohara et al. have succeeded for the first time in creating transchromosomic mice by manipulating spermatogonial stem cells (SSCs), which exhibited superior chromosomal stability compared with embryonic stem cells (ESCs).

中文翻译：

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精原干细胞的忠实人工染色体繁殖

人工染色体可用于为非常大的基因制作功能性载体，研究染色体生理学以及对染色体疾病进行建模。筱原等。通过操纵精原干细胞（SSCs）首次成功创建了转染色体小鼠，与胚胎干细胞（ESCs）相比，精原干细胞具有更好的染色体稳定性。