Cryptococcosis remains a significant cause of morbidity and mortality world-wide, particularly among AIDS patients. Yet, to date, there are no licensed vaccines clinically available to treat or prevent cryptococcosis. In this review, we provide a rationale to support continued investment in Cryptococcus vaccine research, potential challenges that must be overcome along the way, and a literature review of the current progress underway towards developing a vaccine to prevent cryptococcosis.

中文翻译：

---

战斗的号角：寻找隐球菌疫苗

隐球菌病仍然是世界范围内发病和死亡的一个重要原因，特别是在艾滋病患者中。然而，迄今为止，临床上还没有获得许可的疫苗可用于治疗或预防隐球菌病。在这篇综述中，我们提供了支持继续投资隐球菌疫苗研究的理由、必须克服的潜在挑战，以及对当前开发预防隐球菌病疫苗进展的文献综述。