Drugs that act on the brain oxytocin (OXT) system may provide a much-needed treatment breakthrough for substance-use disorders. Targeting the brain OXT system has the potential to treat addiction to all major classes of addictive substance and to intervene across all stages of the addiction cycle. Emerging evidence suggests that OXT is able to interfere with such a wide range of addictive behaviours for such a wide range of addictive substances by rebalancing core neural systems that become dysregulated over the course of addiction. By improving our understanding of these interactions between OXT and the neural substrates of addiction, we will not only improve our understanding of addiction, but also our ability to effectively treat these devastating disorders.

中文翻译：

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重新平衡成瘾的大脑：催产素干扰成瘾的神经底物

作用于大脑催产素 (OXT) 系统的药物可能为物质使用障碍提供急需的治疗突破。针对大脑 OXT 系统有可能治疗对所有主要类型的成瘾物质的成瘾并干预成瘾周期的所有阶段。新出现的证据表明，OXT 能够通过重新平衡在成瘾过程中失调的核心神经系统来干扰如此广泛的成瘾行为。通过提高我们对 OXT 与成瘾神经基质之间这些相互作用的理解，我们不仅将提高我们对成瘾的理解，而且还将提高我们有效治疗这些破坏性疾病的能力。