The Escherichia coli heat shock response (HSR) is a complex mechanism triggered by heat shock and by a variety of other growth-impairing stresses. We explore here the potential use of the E. coli HSR mechanism in synthetic biology approaches. Several components of the regulatory mechanism (such as heat shock promoters, proteins, and RNA thermosensors) can be extremely valuable in the creation of a toolbox of well-characterized biological parts to construct biosensors or microbial cell factories with applications in the environment, industry, or healthcare. In the future, these systems can be used for instance to detect a pollutant in water, to regulate and optimize the production of a compound with industrial relevance, or to administer a therapeutic agent in vivo.

在大肠杆菌的热休克响应（HSR）是通过热激和通过各种其他生长损害应力的触发的复杂的机构。我们在这里探讨了大肠杆菌高铁机制在合成生物学方法中的潜在用途。调节机制的几个组成部分（例如热激启动子，蛋白质和RNA热传感器）在创建功能齐全的生物部件的工具箱（用于构建在环境，工业，或医疗保健。将来，这些系统可用于例如检测水中的污染物，调节和优化具有工业相关性的化合物的生产，或在体内施用治疗剂。