A diverse natural product-like (NPL) synthetic abietane diterpenoid library containing 86 compounds were obtained and the SARs were studied based on their antibacterial potential. Further in vitro cytotoxic and in silico drug-like properties evaluation showed that the potent antibacterial compound 84 had good drug-like properties and displayed low cytotoxicity toward noncancerous mammalian cells, indicating the study of AA and DHAA might be a good starting point for the search of novel antimicrobial molecules. Future work should be focused on the optimization of their potency and selectivity.

中文翻译：

---

鉴定出多种合成的枞树碱二萜类化合物文库，并深入了解抗菌活性的构效关系

获得了包含86种化合物的多样化的类似天然产物（NPL）的合成枞树碱二萜类化合物文库，并根据其抗菌潜力对SAR进行了研究。进一步的体外细胞毒性和计算机模拟药物特性评估表明，强效抗菌化合物84具有良好的药物样特性，并且对非癌性哺乳动物细胞显示出低细胞毒性，这表明对AA和DHAA的研究可能是寻找该化合物的良好起点。新的抗菌分子。未来的工作应集中在优化其效价和选择性上。