A series of glutamic acid derivatives was synthesized and evaluated for their antioxidant activity and stability. We found several potent and stable glutamic acid derivatives. Among them, compound 12b exhibited good in vitro activity, chemical stability and cytotoxicity. A prototype compound 12b showed an anti-inflammatory effect in LPS-stimulated RAW 264.7 cell lines and in a zebrafish model.

中文翻译：

---

谷氨酸衍生物作为抗氧化剂和消炎药的设计，合成及生物学评价

合成了一系列谷氨酸衍生物，并评估了其抗氧化活性和稳定性。我们发现了几种有效且稳定的谷氨酸衍生物。其中，化合物12b显示出良好的体外活性，化学稳定性和细胞毒性。原型化合物12b在LPS刺激的RAW 264.7细胞系和斑马鱼模型中显示出抗炎作用。