A series of arylalkanol and aralkyl piperazine derivatives have been synthesized and evaluated for 5-HT reuptake inhibitory abilities and binding affinities at the 5-HT_1A/5-HT₇ receptors. Antidepressant activities of the compounds in vivo were screened using the forced swimming test (FST). The results indicated that the compound 8j exhibited high affinities for the 5-HT_1A/5-HT₇ receptors (5-HT_1A, k_i = 0.84 nM; 5-HT₇, k_i = 12 nM) coupling with moderate 5-HT reuptake inhibitory activity (RUI, IC₅₀ = 100 nM) and showed a marked antidepressant-like activity in the FST model.

中文翻译：

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一系列针对SSRI / 5-HT _1A / 5-HT ₇的芳基链烷醇和芳烷基哌嗪衍生物的合成和抗抑郁活性

已经合成了一系列芳基链烷醇和芳烷基哌嗪衍生物，并评估了其对5-HT _1A / 5-HT ₇受体的5-HT再摄取抑制能力和结合亲和力。使用强制游泳试验（FST）筛选了这些化合物在体内的抗抑郁活性。结果表明，化合物8j对5-HT _1A / 5-HT ₇受体（5-HT _1A，k _i  = 0.84 nM； 5-HT ₇，ki _i  = 12 nM）具有中等亲和力的高亲和力。HT再摄取抑制活性（RUI，IC ₅₀ = 100 nM），并在FST模型中显示出明显的抗抑郁样活性。