One new highly oxygenated nortriterpene, named sieverlactone (1), one new sesquiterpene, 1β,10β-epoxy-8α-acetoxyachillin (2), one new natural product, 5-propinyl-thiophene-2-carboxylic acid (3), and one new thiophene, 3-hydroxy-5-propinyl-2-acetyl-thiophene (4), together with 10 other known compounds (5−14), were isolated from the dried aerial parts of Artemisia sieversiana. Their structures were elucidated by a combination of extensive spectroscopic analysis, including 1D, 2D NMR spectroscopic and mass spectrometric data. Meanwhile, the stereochemistry of 1 and 2 was confirmed by single-crystal X-ray diffraction technique using Cu radiation. All the isolates were evaluated for their anti-neuroinflammatory effects on the lipopolysaccharide-induced nitric oxide production in BV-2 murine microglial cells. Compounds 2, 5, and 6 exhibited the significant activities with IC₅₀ values of 6.5 ± 0.5, 11.9 ± 0.7, and 10.1 ± 0.3 μM, respectively, comparable to the positive control, quercetin, with an IC₅₀ value of 16.3 ± 0.4 μM.

一个新的高度氧化nortriterpene，命名sieverlactone（1），一个新的倍半萜烯，1个β，10 β -环氧-8 α -acetoxyachillin（2），一个新的天然产物，5-丙炔基-噻吩-2-羧酸（3）和一个新的噻吩，3-羟基-5-丙炔基-2-乙酰基噻吩（4），连同10种其它已知化合物（5 - 14），购自的干燥地上部分分离蒿碱地肤。通过广泛的光谱分析（包括1D，2D NMR光谱和质谱数据）的组合阐明了它们的结构。同时，1的立体化学和2通过使用Cu辐射的单晶X射线衍射技术证实。评价所有分离物对BV-2鼠小神经胶质细胞中脂多糖诱导的一氧化氮产生的抗神经炎作用。化合物2，5，和6个表现出显著活动，IC _50倍为6.5±0.5的值，11.9±0.7，和10.1±0.3μM，分别与阳性对照，槲皮素，与IC ₅₀ 16.3±0.4μM的值。