Enantioselective palladium-catalyzed C–H functionalization of pyrroles using an axially chiral 2,2′-bipyridine ligand,Organic Chemistry Frontiers

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Enantioselective palladium-catalyzed C–H functionalization of pyrroles using an axially chiral 2,2′-bipyridine ligand
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2017-11-06 00:00:00 , DOI: 10.1039/c7qo00815e
Hong-Qiang Shen _{1,

2,

3,

4,

5} , Cong Liu _{1,

2,

3,

4,

5} , Ji Zhou _{1,

2,

3,

4,

5} , Yong-Gui Zhou _{1,

2,

3,

4,

5}

Affiliation

An enantioselective C–H functionalization of pyrrole derivatives with diazo compounds has been successfully realized with up to 90% ee by employing dichlorobis(benzonitrile)palladium with an axially chiral bipyridine ligand C3-ACBP as the catalyst. Asymmetric C–H functionalization at the gram scale was also conducted smoothly with good reactivity and enantioselectivity.

中文翻译：

使用轴向手性2,2'-联吡啶配体的对映体钯催化吡咯的CH-H官能化

通过使用二氯双（苄腈）钯和轴向手性联吡啶配体C3-ACBP作为催化剂，成功地实现了重氮对吡咯衍生物与重氮化合物的对映选择性C–H功能化，收率高达90％。克级的不对称C–H功能化也能顺利进行，并具有良好的反应性和对映选择性。

更新日期：2017-11-10

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