Dimerization of Phenylalanine: An Approach to Thiazoles and Oxazoles Involved S/O‐Insertion,Advanced Synthesis & Catalysis

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Dimerization of Phenylalanine: An Approach to Thiazoles and Oxazoles Involved S/O‐Insertion
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2017-11-30 , DOI: 10.1002/adsc.201701130
Yan Cheng ₁ , Jia-Chen Xiang ₁ , Zi-Xuan Wang ₁ , Jin-Tian Ma ₁ , Miao Wang ₁ , Bo-Cheng Tang ₁ , Yan-Dong Wu ₁ , Yan-Ping Zhu ₂ , An-Xin Wu ₁

Affiliation

We herein describe the development of a dimerization procedure for amino acids to prepare 2,5‐disubstituted thiazoles and oxazoles in the presence of Na₂S⋅9H₂O and H₂O, respectively. These approaches enabled the direct formation of five‐membered ring systems bearing two different heteroatoms from two amino acid units. Mechanically, decarboxylation, deamination, S/O insertion, cyclization and gradient oxidation processes were involved in the oligomer formation.

中文翻译：

苯丙氨酸的二聚化：噻唑和恶唑涉及S / O插入的一种方法

本文中，我们描述一个二聚化过程的发展，为氨基酸以制备钠的存在下2,5-二取代的噻唑和恶唑₂ S⋅9H ₂氧，氢₂，分别O操作。这些方法能够直接形成带有两个氨基酸单元中两个不同杂原子的五元环系统。在机械上，脱羧，脱氨基，S / O插入，环化和梯度氧化过程涉及低聚物的形成。

更新日期：2017-11-30

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