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Cell Factory Design and Optimization for the Stereoselective Synthesis of Polyhydroxylated Compounds
ChemBioChem ( IF 2.6 ) Pub Date : 2017-11-09 12:46:34 , DOI: 10.1002/cbic.201700464 Thomas Wiesinger 1 , Thomas Bayer 1 , Sofia Milker 1 , Marko D. Mihovilovic 1 , Florian Rudroff 1
ChemBioChem ( IF 2.6 ) Pub Date : 2017-11-09 12:46:34 , DOI: 10.1002/cbic.201700464 Thomas Wiesinger 1 , Thomas Bayer 1 , Sofia Milker 1 , Marko D. Mihovilovic 1 , Florian Rudroff 1
Affiliation
Cascades in cells: A synthetic cascade for the transformation of primary alcohols into polyhydroxylated compounds through in situ preparation of cytotoxic aldehyde intermediates and subsequent aldolase-mediated C−C bond formation is investigated. The optimized whole-cell catalyst, combined with a refined solid-phase extraction downstream purification protocol gives optically pure aldol products.
中文翻译:
多羟基化合物立体选择性合成的细胞工厂设计和优化
细胞级联:研究了通过原位制备细胞毒性醛中间体并随后醛缩酶介导的C-C键形成将伯醇转化为多羟基化合物的合成级联反应。经过优化的全细胞催化剂,再结合精制的固相萃取下游纯化方案,可得到光学纯的醛醇产物。
更新日期:2017-11-09
中文翻译:
多羟基化合物立体选择性合成的细胞工厂设计和优化
细胞级联:研究了通过原位制备细胞毒性醛中间体并随后醛缩酶介导的C-C键形成将伯醇转化为多羟基化合物的合成级联反应。经过优化的全细胞催化剂,再结合精制的固相萃取下游纯化方案,可得到光学纯的醛醇产物。