Cell Factory Design and Optimization for the Stereoselective Synthesis of Polyhydroxylated Compounds,ChemBioChem

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Cell Factory Design and Optimization for the Stereoselective Synthesis of Polyhydroxylated Compounds
ChemBioChem ( IF 2.6 ) Pub Date : 2017-11-09 12:46:34 , DOI: 10.1002/cbic.201700464
Thomas Wiesinger ₁ , Thomas Bayer ₁ , Sofia Milker ₁ , Marko D. Mihovilovic ₁ , Florian Rudroff ₁

Affiliation

Cascades in cells: A synthetic cascade for the transformation of primary alcohols into polyhydroxylated compounds through in situ preparation of cytotoxic aldehyde intermediates and subsequent aldolase-mediated C−C bond formation is investigated. The optimized whole-cell catalyst, combined with a refined solid-phase extraction downstream purification protocol gives optically pure aldol products.

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