Coordination-driven assembly of catechol-modified chitosan for the kidney-specific delivery of salvianolic acid B to treat renal fibrosis†,Biomaterials Science

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Coordination-driven assembly of catechol-modified chitosan for the kidney-specific delivery of salvianolic acid B to treat renal fibrosis†
Biomaterials Science ( IF 5.8 ) Pub Date : 2017-11-09 00:00:00 , DOI: 10.1039/c7bm00811b
Jing Li _{1,

2,

3,

4} , Cuiting Zhang _{1,

2,

3,

4} , Weiming He _{3,

4,

5} , Hongzhi Qiao _{1,

2,

3,

4} , Jiahui Chen _{1,

2,

3,

4} , KaiKai Wang _{1,

2,

3,

4} , David Oupický _{1,

2,

3,

4,

6} , Minjie Sun _{1,

2,

3,

4}

Affiliation

Kidney-specific delivery is critically important for the treatment of renal fibrosis with drugs such as salvianolic acid B (Sal B). Here we report a kidney-specific nanocomplex formed by the coordination-driven assembly of catechol-modified low molecular weight chitosan (HCA-Chi), calcium ions and Sal B. The prepared HCA-Chi-Ca-Sal B (HChi-Ca-Sal B) nanocomplex reversed the TGF-β1-induced epithelial–mesenchymal transition (EMT) in HK-2 cells. In vivo imaging demonstrated a kidney-specific biodistribution of the nanocomplex. The anti-fibrosis effect of HChi-Ca-Sal B was tested in a mouse model of unilateral ureteral obstruction (UUO). Significant attenuation of the morphological lesions and the levels of extracellular matrix (ECM) proteins in the tubulointerstitium was observed in mice treated with HChi-Ca-Sal B, suggesting that the nanocomplex was able to prevent fibrosis better than the treatment with free Sal B. It was concluded that the HChi-Ca-Sal B nanocomplex showed a specific renal targeting capacity and could be utilized to enhance Sal B delivery for treating renal fibrosis.

中文翻译：

协调驱动的邻苯二酚改性壳聚糖组装，用于肾特异性丹酚酸B的递送以治疗肾纤维化†

肾脏特异性分娩对于使用丹酚酸B（Sal B）等药物治疗肾纤维化至关重要。在这里，我们报告由儿茶酚改性的低分子量壳聚糖（HCA-Chi），钙离子和Sal B的配位驱动组装形成的肾脏特异性纳米复合物。制备的HCA-Chi-Ca-Sal B（HChi-Ca- Sal B）纳米复合物逆转了HK-2细胞中TGF-β1诱导的上皮-间质转化（EMT）。体内成像证实了纳米复合物的肾脏特异性生物分布。在单侧输尿管梗阻（UUO）小鼠模型中测试了HChi-Ca-Sal B的抗纤维化作用。在用HChi-Ca-Sal B处理的小鼠中观察到了肾小管间质中形态损伤和细胞外基质（ECM）蛋白水平的显着减弱，这表明纳米复合物比游离Sal B能够更好地预防纤维化。结论是，HChi-Ca-Sal B纳米复合物显示出特定的肾脏靶向能力，可用于增强Sal B的递送以治疗肾纤维化。

更新日期：2017-11-09

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