A practical synthesis of 2,3-dihydro-1,5-benzothiazepines,Green Chemistry

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A practical synthesis of 2,3-dihydro-1,5-benzothiazepines
Green Chemistry ( IF 9.3 ) Pub Date : 2017-10-30 00:00:00 , DOI: 10.1039/c7gc02097j
Domenico C. M. Albanese _{1,

2,

3,

4} , Nicoletta Gaggero _{2,

3,

4,

5} , Meng Fei _{2,

3,

4,

5}

Affiliation

2,3-Dihydro-1,5-benzothiazepines have been obtained through a domino process involving a Michael addition of 2-aminothiophenols to chalcones, followed by in situ cyclization. Up to 98% chemical yields have been obtained at room temperature under essentially neutral conditions by using hexafluoro-2-propanol as an efficient medium.

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