Schizophrenia and bipolar disorder (BD) are heritable disorders with similarities in clinical symptoms and typical onset after puberty.¹ While research shows that impaired motor coordination can have an association with schizophrenia,² there are limited data on childhood development preceding BD. Murray et al¹ proposed a developmental model for similarities and dissimilarities between schizophrenia and BD, but it remains unknown if dissimilarities exist in early infancy and if they covary with genetic liability for these disorders. Using polygenic risk scores (PRSs), we explored whether genetic risk for schizophrenia and genetic risk for BD are associated with neuromotor development in infancy.

精神分裂症和双相情感障碍（BD）是可遗传性疾病，其临床症状相似，并且在青春期后典型发作。¹虽然研究表明运动协调障碍可能与精神分裂症有关，但²关于BD之前儿童发育的数据有限。Murray等[ ^1]提出了一种针对精神分裂症和BD的相似性和异同性的发展模型，但是对于婴儿早期是否存在异同以及这些疾病是否与遗传易感性尚不明确。使用多基因风险评分（PRS），我们探讨了精神分裂症的遗传风险和BD的遗传风险是否与婴儿的神经运动发育有关。