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Treating Recurrent Glioma with Toca 511
Cancer Discovery ( IF 29.7 ) Pub Date : 2018-01-01 , DOI: 10.1158/2159-8290.cd-nb2017-157 American Association for Cancer Research
中文翻译:
用Toca 511治疗复发性脑胶质瘤
更新日期:2018-01-08
Cancer Discovery ( IF 29.7 ) Pub Date : 2018-01-01 , DOI: 10.1158/2159-8290.cd-nb2017-157 American Association for Cancer Research
Findings from a phase I study suggest that delivering high concentrations of the chemotherapy 5-FU directly to brain tumors via the retroviral vector vocimagene amiretrorepvec, or Toca 511, may benefit patients with recurrent high-grade glioma. This investigational treatment was well tolerated and induced robust, durable responses lasting a median of 3 years.
中文翻译:
用Toca 511治疗复发性脑胶质瘤
I期研究的结果表明,通过逆转录病毒载体vocimagene amiretrorepvec或Toca 511将高浓度的化学疗法5-FU直接递送至脑肿瘤可能会使复发性高级别胶质瘤患者受益。这种研究治疗方法具有良好的耐受性,可引起持续3年的强烈而持久的反应。