Findings from a phase I study suggest that delivering high concentrations of the chemotherapy 5-FU directly to brain tumors via the retroviral vector vocimagene amiretrorepvec, or Toca 511, may benefit patients with recurrent high-grade glioma. This investigational treatment was well tolerated and induced robust, durable responses lasting a median of 3 years.

中文翻译：

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用Toca 511治疗复发性脑胶质瘤

I期研究的结果表明，通过逆转录病毒载体vocimagene amiretrorepvec或Toca 511将高浓度的化学疗法5-FU直接递送至脑肿瘤可能会使复发性高级别胶质瘤患者受益。这种研究治疗方法具有良好的耐受性，可引起持续3年的强烈而持久的反应。