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A photo-cleavable polyprodrug-loaded wound dressing with UV-responsive antibacterial property
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2017-10-23 00:00:00 , DOI: 10.1039/c7tb01696d Qian Pang 1, 2, 3, 4, 5 , Xiaowen Zheng 1, 2, 3, 4, 5 , Yu Luo 1, 2, 3, 4, 5 , Lie Ma 1, 2, 3, 4, 5 , Changyou Gao 1, 2, 3, 4, 5
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2017-10-23 00:00:00 , DOI: 10.1039/c7tb01696d Qian Pang 1, 2, 3, 4, 5 , Xiaowen Zheng 1, 2, 3, 4, 5 , Yu Luo 1, 2, 3, 4, 5 , Lie Ma 1, 2, 3, 4, 5 , Changyou Gao 1, 2, 3, 4, 5
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The development of antibiotic-loaded wound dressings is of great importance in wound healing and infection treatment. However, in traditional antibiotic-loaded wound dressings, antibiotics are released uncontrollably from the dressings primarily by passive diffusion. The overuse of antibiotics may lead to drug resistance and side effects, which could hinder the healing process. To overcome these shortcomings, a wound dressing with UV-responsive antibacterial property was developed in this study. Levofloxacin (LF) was first conjugated to amine-terminated poly(ethylene glycol) through a photolabile ortho-nitrobenzyl linker to obtain a photo-cleavable polyprodrug (LHP), which was then loaded into a poly(vinyl alcohol)/sodium alginate (PVA/SA) wound dressing. Compared to the PVA/SA dressing, the LHP-loaded dressing showed larger swelling capacity and retained good cytocompatibility. It was found that LF could be cleaved from LHP under UV irradiation at 365 nm and released gradually from the wound dressing with an increase in UV irradiation time. The antibacterial zone test proved that the LHP-loaded wound dressing possessed UV-responsive antibacterial properties against Staphylococcus aureus.
中文翻译：
具有紫外线响应抗菌特性的可光裂解的载有前药的伤口敷料
载有抗生素的伤口敷料的开发在伤口愈合和感染治疗中非常重要。然而，在传统的载有抗生素的伤口敷料中，主要通过被动扩散使抗生素从敷料中不受控制地释放。过度使用抗生素可能导致耐药性和副作用，这可能会阻碍愈合过程。为了克服这些缺点，在这项研究中开发了具有紫外线响应抗菌特性的伤口敷料。左氧氟沙星（LF）首先通过对光不稳定的邻位基团与胺封端的聚乙二醇偶联-硝基苄基接头获得光可裂解的聚前药（LHP），然后将其加载到聚乙烯醇/海藻酸钠（PVA / SA）伤口敷料中。与PVA / SA敷料相比，LHP敷料具有更大的溶胀能力并保持了良好的细胞相容性。发现在365nm的紫外线照射下，LF可以从LHP上裂解下来，并随着紫外线照射时间的增加而逐渐从伤口敷料中释放出来。抗菌区测试证明，载有LHP的伤口敷料对金黄色葡萄球菌具有紫外线响应的抗菌性能。
更新日期：2017-11-08
中文翻译：
具有紫外线响应抗菌特性的可光裂解的载有前药的伤口敷料
载有抗生素的伤口敷料的开发在伤口愈合和感染治疗中非常重要。然而，在传统的载有抗生素的伤口敷料中，主要通过被动扩散使抗生素从敷料中不受控制地释放。过度使用抗生素可能导致耐药性和副作用，这可能会阻碍愈合过程。为了克服这些缺点，在这项研究中开发了具有紫外线响应抗菌特性的伤口敷料。左氧氟沙星（LF）首先通过对光不稳定的邻位基团与胺封端的聚乙二醇偶联-硝基苄基接头获得光可裂解的聚前药（LHP），然后将其加载到聚乙烯醇/海藻酸钠（PVA / SA）伤口敷料中。与PVA / SA敷料相比，LHP敷料具有更大的溶胀能力并保持了良好的细胞相容性。发现在365nm的紫外线照射下，LF可以从LHP上裂解下来，并随着紫外线照射时间的增加而逐渐从伤口敷料中释放出来。抗菌区测试证明，载有LHP的伤口敷料对金黄色葡萄球菌具有紫外线响应的抗菌性能。
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