Construction of the tetrahydroquinoline spiro skeleton via cascade [1,5]-hydride transfer-involved C(sp3)–H functionalization “on water”,Green Chemistry

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Construction of the tetrahydroquinoline spiro skeleton via cascade [1,5]-hydride transfer-involved C(sp3)–H functionalization “on water”
Green Chemistry ( IF 9.3 ) Pub Date : 2017-10-24 00:00:00 , DOI: 10.1039/c7gc02353g
Shuai Zhu _{1,

2,

3,

4} , Chunqi Chen _{1,

2,

3,

4} , Mingyan Xiao _{1,

2,

3,

4} , Liping Yu _{1,

2,

3,

4} , Liang Wang _{1,

2,

3,

4} , Jian Xiao _{1,

2,

3,

4}

Affiliation

The pharmaceutically important tetrahydroquinoline spiro compounds were efficiently constructed via cascade S_NAr/Knoevenagel condensation/[1,5]-hydride transfer/cyclization on water, featuring high atom-economy and step-economy. This water-based redox-neutral C(sp³)–H functionalization rendered a 4-step cascade reaction successful without resorting to any catalysts.

中文翻译：

通过[1,5]-氢化物转移涉及的C（sp ³）–H官能化“在水上”构建四氢喹啉螺骨架

药学上重要的四氢喹啉螺环化合物是通过级联S _N Ar / Knoevenagel缩合/ [1,5]-氢化物转移/环化在水上高效构建的，具有高原子经济性和阶梯经济性。这种水基氧化还原中性的C（sp ³）–H官能化使四步级联反应成功进行，而无需借助任何催化剂。

更新日期：2017-11-08

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