Solvent-controlled highly regio-selective thieno[2,3-b]indole formation under metal-free conditions,Green Chemistry

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Solvent-controlled highly regio-selective thieno[2,3-b]indole formation under metal-free conditions
Green Chemistry ( IF 9.3 ) Pub Date : 2017-10-24 00:00:00 , DOI: 10.1039/c7gc02818k
Penghui Ni _{1,

2,

3,

4,

5} , Bin Li _{1,

2,

3,

4,

5} , Huawen Huang _{1,

2,

3,

4,

5} , Fuhong Xiao _{1,

2,

3,

4,

5} , Guo-Jun Deng _{1,

2,

3,

4,

5}

Affiliation

An efficient three-component thieno[2,3-b]indole formation method was developed under metal-free conditions. The cascade cyclization was enabled by acid-promoted annulation of indoles, ketones and sulfur powder, which enabled modular synthesis of 2-substituted and 3-substituted thieno[2,3-b]indoles with excellent regioselectivity and broad functional group tolerance. DMF solvent played an important role in the regioselectivity control.

中文翻译：

在无金属条件下溶剂控制的高度区域选择性噻吩并[2,3- b ]吲哚的形成

在无金属条件下，开发了一种高效的三组分噻吩并[2,3- b ]吲哚形成方法。级联环化是通过吲哚，酮和硫粉的酸促进环合实现的，从而可以模块化合成2-取代和3-取代的噻吩并[2,3- b ]吲哚，具有出色的区域选择性和宽泛的官能团耐受性。DMF溶剂在区域选择性控制中起着重要作用。

更新日期：2017-11-08

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