A base-free, ultrasound accelerated one-pot synthesis of 2-sulfonylquinolines in water,Green Chemistry

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A base-free, ultrasound accelerated one-pot synthesis of 2-sulfonylquinolines in water
Green Chemistry ( IF 9.3 ) Pub Date : 2017-10-16 00:00:00 , DOI: 10.1039/c7gc02304a
Long-Yong Xie _{1,

2,

3,

4,

5} , Yong-Jian Li _{1,

2,

3,

4,

5} , Jie Qu _{1,

2,

3,

4,

5} , Yue Duan _{1,

2,

3,

4,

5} , Jue Hu _{1,

2,

3,

4,

5} , Kai-Jian Liu _{1,

2,

3,

4,

5} , Zhong Cao _{1,

2,

3,

4,

5} , Wei-Min He _{1,

2,

3,

4,

5}

Affiliation

Without employing any base and organic solvent, an economical, practical and eco-friendly protocol has been developed for the one-pot synthesis of various functionalized 2-sulfonylquinolines from easily accessible starting materials in water under open-air conditions. Compared with conventional heating conditions, the use of ultrasound techniques not only improves the reaction efficiency and enhances the reaction rate but also minimizes the side reactions. This process has a broad substrate scope, mild reaction conditions, good yields, excellent chemo- and regioselectivities, operational simplicity, ease of scale-up and high energy efficiency. In addition, the process is remarkably greener than the previous routes with an atom economy of 70.7%, an E-factor of 1.17 and an eco-scale score of 71.

中文翻译：

无碱，超声加速一锅合成水中的2-磺酰基喹啉

在不使用任何碱和有机溶剂的情况下，已经开发了一种经济，实用和环保的方案，用于在露天条件下从水中容易获得的起始原料一锅合成各种功能化的2-磺酰基喹啉。与常规加热条件相比，超声技术的使用不仅提高了反应效率，提高了反应速率，而且使副反应最小化。该方法具有广泛的底物范围，温和的反应条件，良好的收率，优异的化学和区域选择性，操作简便，易于规模化和高能源效率。此外，该过程比以前的路线更加环保，其原子经济率为70.7％，E因子为1.17，生态规模得分为71。

更新日期：2017-11-08

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