Enantioselective synthesis of gem-diarylalkanes by transition metal-catalyzed asymmetric arylations (TMCAAr),Chemical Science

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Enantioselective synthesis of gem-diarylalkanes by transition metal-catalyzed asymmetric arylations (TMCAAr)
Chemical Science ( IF 7.6 ) Pub Date : 2017-11-08 00:00:00 , DOI: 10.1039/c7sc03404k
Tao Jia _{1,

2} , Peng Cao ₂ , Jian Liao _{1,

3}

Affiliation

Chiral gem(1,1)-diaryl containing tertiary or quaternary stereogenic centers are present in many natural products and important pharmacophores. While numerous catalytic asymmetric methods enable access to 1,1-diaryl motifs, transition metal-catalyzed asymmetric arylations (TMCAAr) are one of the most powerful methods to prepare enantiopure gem-diarylalkane compounds. The main methodology includes enantioselective 1,2- or 1,4-additions across C [double bond, length as m-dash]

O, C

N and C

C bonds by arylmetallic reagents; aryl cross-couplings of olefins, benzylic (pseudo)halides and aziridines; asymmetric aryl substitution reactions of allylic substrates; and isotopic benzylic C–H arylation.

中文翻译：

过渡金属催化不对称芳基化 (TMCAAr) 对映选择性合成偕二芳基烷烃

手性宝石(1,1)-二芳基含有叔或季立体中心存在于许多天然产物和重要的药效团中。虽然许多催化不对称方法能够获得 1,1-二芳基基序，但过渡金属催化的不对称芳基化 (TMCAAr) 是制备对映体纯宝石-二芳基烷烃化合物的最有效方法之一。主要方法包括通过芳基金属试剂在 C [双键，长度为 m-dash]