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Facile Synthesis of Sulfobetaine-Stabilized Cu2O Nanoparticles and Their Biomedical Potential
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2017-11-07 00:00:00 , DOI: 10.1021/acsbiomaterials.7b00465
Marta J. Woźniak-Budych 1 , Łucja Przysiecka 1 , Barbara M. Maciejewska 1 , Daria Wieczorek 2 , Katarzyna Staszak 3 , Marcin Jarek 1 , Teofil Jesionowski 3 , Stefan Jurga 1
Affiliation  

A novel approach using a zwitterionic sulfobetaine-based surfactant for the synthesis of spherical copper oxide nanoparticles (Cu2O NPs) has been applied. For the first time, N-hexadecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate has been used as stabilizer to control the size and morphology of Cu2O NPs. Several techniques, such as transmission electron microscopy (TEM), X-ray diffraction (XRD), and fluorescence spectroscopy, are used to investigate the size, structure, and optical properties of synthesized Cu2O nanocrystals. The results indicate that copper(I) oxide nanoparticles with size in the range of 2 to 45 nm and crystalline structure, exhibit intense yellow fluorescence (λem = 575 nm). Furthermore, the cytotoxicity studies show that sulfobetaine-stabilized copper oxide nanoparticles prompt inhibition of cancer cell proliferation in a concentration-dependent manner, however, the adverse effect on the normal cells has also been observed. The results indicate that the sulfobetaine-stabilized Cu2O, because of their unique properties, have a potential to be applied in medical fields, such as cancer therapy and bioimaging.

中文翻译:

磺基甜菜碱稳定的Cu 2 O纳米粒子的简便合成及其生物医学潜力

已经应用了一种基于两性离子磺基甜菜碱的表面活性剂来合成球形氧化铜纳米颗粒(Cu 2 O NPs)的新方法。第一次,N-十六烷基-N,N-二甲基-3-铵-1-丙烷磺酸盐被用作稳定剂,以控制Cu 2 O NP的大小和形态。几种技术,例如透射电子显微镜(TEM),X射线衍射(XRD)和荧光光谱,用于研究合成的Cu 2 O纳米晶体的尺寸,结构和光学性质。结果表明,尺寸在2至45 nm范围内且具有晶体结构的氧化铜(I)纳米颗粒表现出强烈的黄色荧光(λem= 575 nm)。此外,细胞毒性研究表明,磺基甜菜碱稳定的氧化铜纳米颗粒以浓度依赖的方式促进癌细胞的增殖抑制,但是,还观察到了对正常细胞的不利影响。结果表明,由于磺基甜菜碱稳定的Cu 2 O具有独特的性能,因此具有在医学领域(如癌症治疗和生物成像)中应用的潜力。
更新日期:2017-11-08
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