Antipseudomonal activity enhancement of luminescent iridium(iii) dipyridylamine complexes under visible blue light†‡,Metallomics

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Antipseudomonal activity enhancement of luminescent iridium(iii) dipyridylamine complexes under visible blue light†‡
Metallomics ( IF 2.9 ) Pub Date : 2017-11-08 00:00:00 , DOI: 10.1039/c7mt00262a
E. Sauvageot _{1,

2,

3,

4,

5} , M. Elie _{1,

2,

3,

4,

5} , S. Gaillard _{1,

2,

3,

4,

5} , R. Daniellou _{6,

7,

8} , P. Fechter _{5,

8,

9,

10,

11} , I. J. Schalk _{5,

8,

9,

10,

11} , V. Gasser _{5,

8,

9,

10,

11} , J.-L. Renaud _{1,

2,

3,

4,

5} , G. L. A. Mislin _{5,

8,

9,

10,

11}

Affiliation

Cyclometallated iridium(III) dipyridylamine complexes present antibacterial activity against P. aeruginosa, a highly resistant pathogenic bacterium. This activity is increased when the complex is conjugated to biotin, a bacterial nutrient, and a MIC of 4 μM (4 μg mL⁻¹) has been observed. The irradiation of P. aeruginosa cultures with blue LED light potentiates the anti-bacterial activities of these iridium(III) complexes when they are conjugated to a glycoside.

中文翻译：

发光的铱的抗假单胞菌活性增强（三）下可见的蓝光吡啶胺配合† ‡

环金属化铱（III）二吡啶胺复合物对铜绿假单胞菌（一种高度耐药的致病细菌）具有抗菌活性。当复合物与生物素，细菌营养物结合并且观察到MIC为4μM（4μgmL ^-1）时，该活性增加。蓝色铱光照射铜绿假单胞菌培养物可增强这些铱（III）配合物与糖苷结合时的抗菌活性。

更新日期：2017-11-08

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