A method for electrooxidative C(sp3)–H amination via intermolecular oxidative C(sp3)–H/N–H cross-coupling has been developed under metal- and oxidant-free conditions. The C(sp3)–H bonds adjacent to oxygen, nitrogen, and sulfur atoms could all react smoothly with various amines to give the corresponding products with moderate to good yields (30–93%). In addition, the C(sp3)–H bonds of benzylic and allylic are also tolerated in this reaction. A preliminary mechanistic study indicates that the C–H cleavage of tetrahydrofuran is probably not involved in the rate-determining step.

中文翻译：

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通过分子间氧化性C（sp3）–H / N–H交叉偶合对腈进行电氧化C（sp3）–H胺化

已经开发了一种在无金属和无氧化剂条件下通过分子间氧化C（sp3）-H / N-H交叉偶联进行电氧化C（sp3）-H胺化的方法。与氧，氮和硫原子相邻的C（sp3）–H键均可以与各种胺顺利反应，从而以中等至良好的收率（30–93％）得到相应的产物。此外，该反应中还可以耐受苄基和烯丙基的C（sp3）–H键。初步的机理研究表明，四氢呋喃的C–H裂解可能不参与速率测定步骤。