Iron Catalyzed Hydroboration of Aldehydes and Ketones,The Journal of Organic Chemistry

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Iron Catalyzed Hydroboration of Aldehydes and Ketones
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2017-11-07 00:00:00 , DOI: 10.1021/acs.joc.7b02020
Sem Raj Tamang ₁ , Michael Findlater ₁

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We report an operationally convenient room temperature hydroboration of aldehydes and ketones employing Fe(acac)₃ as precatalyst. The hydroboration of aldehydes and ketones proceeded efficiently at room temperature to yield, after work up, 1° and 2° alcohols; chemoselective hydroboration of aldehydes over ketones is attained under these conditions. We propose a σ-bond metathesis mechanism in which an Fe–H intermediate is postulated to be a key reactive species.

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