当前位置: X-MOL 学术J. Org. Chem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Camphorsulfonic Acid Catalyzed One-Pot Three-Component Reaction for the Synthesis of Fused Quinoline and Benzoquinoline Derivatives
The Journal of Organic Chemistry ( IF 3.6 ) Pub Date : 2017-11-07 00:00:00 , DOI: 10.1021/acs.joc.7b02159
Radhakrishna Gattu 1 , Prasanta Ray Bagdi 1 , R. Sidick Basha 1 , Abu T. Khan 1
Affiliation  

A simple and an efficient one-pot three-component reaction of arylamines, aromatic aldehydes, and cyclic ketones was described for the synthesis of various fused quinoline, benzoquinoline, and naphthoquinoline derivatives by using camphorsulfonic acid as a catalyst. The exploitation of pregnenolone steroid for benzoquinolines and terephthalaldehyde for bis-benzoquinolines synthesis was achieved with 68–75% yields. The reactivity of arylamines and the mechanistic study for the formation of benzoquinoline was described precisely. The present protocol offers a great potential for atom-economy under mild conditions.

中文翻译:

樟脑磺酸催化一锅三组分反应合成熔融喹啉和苯并喹啉衍生物

描述了一种简单高效的芳胺,芳族醛和环状酮的一锅三组分反应,用于通过使用樟脑磺酸作为催化剂来合成各种稠合喹啉,苯并喹啉和萘喹啉衍生物。孕烯醇酮类固醇用于苯并喹啉的开发,对苯二甲醛用于双苯并喹啉的合成,收率为68-75%。精确描述了芳基胺的反应性和形成苯并喹啉的机理的研究。本协议在温和条件下为原子经济提供了巨大潜力。
更新日期:2017-11-08
down
wechat
bug