A domino reaction with the organocatalytic enantioselective Michael–acetalization–Henry reaction of 2-hydroxynitrostyrene and 5-oxohexanal was developed for the synthesis of hexahydro-6H-benzo[c]chromenones with four consecutive stereogenic centers and high enantioselectivity (up to >99% ee). The transformation of a NaBH₄-reduced adduct to the aflatoxin system via the Nef-cyclization process was achieved by the assistant of ZnBr₂.

中文翻译：

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2-羟基硝基苯乙烯和5-氧己醛进入具有四个连续立体中心的六氢-6 H-苯并[ c ]色酮的有机催化对映选择性迈克尔-乙酰化-亨利反应级联和一种黄曲霉毒素类似物的方法

已开发出一种具有2-羟基硝基苯乙烯和5-氧己醛的有机催化对映选择性迈克尔-缩醛化-亨利反应的多米诺反应，用于合成具有四个连续立体中心和高对映选择性（最高> 99的六氢-6 H-苯并[ c ]色酮）。％ee）。通过ZnBr ₂的辅助，通过Nef环化过程将NaBH ₄还原的加合物转化为黄曲霉毒素体系。