General and Catalytic Enantioselective Approach to Isopavine Alkaloids,The Journal of Organic Chemistry

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General and Catalytic Enantioselective Approach to Isopavine Alkaloids
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2017-11-07 00:00:00 , DOI: 10.1021/acs.joc.7b02385
Lingyu Sun ₁ , Da Li ₁ , Xiaowei Zhou ₁ , Dongxu Zhang ₁ , Jin Wang ₁ , Zhongjing He ₂ , Ru Jiang ₁ , Weiping Chen ₁

Affiliation

A concise, versatile, and catalytic enantioselective approach to natural and non-natural isopavine alkaloids has been developed. The synthesis takes advantage of catalytic asymmetric reaction to construct the pivotal stereogenic center in a highly enantioselective way (95–98% ee), and features use of intramolecular Pictet–Spengler reaction to build the core tetracyclic skeleton in a rapid and stereoselective fashion.

中文翻译：

异链烷生物碱的常规和催化对映选择性方法

已经开发出一种对天然和非天然异链烷生物碱的简洁，通用和催化对映选择性的方法。合成利用催化不对称反应以高度对映选择性的方式（95-98％ee）构建关键的立体生成中心，并具有利用分子内Pictet-Spengler反应以快速和立体选择性的方式构建核心四环骨架的特征。

更新日期：2017-11-08

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