Cancer Therapy: Nutlin‐3a and Cytokine Co‐loaded Spermine‐Modified Acetalated Dextran Nanoparticles for Cancer Chemo‐Immunotherapy (Adv. Funct. Mater. 42/2017),Advanced Functional Materials

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Cancer Therapy: Nutlin‐3a and Cytokine Co‐loaded Spermine‐Modified Acetalated Dextran Nanoparticles for Cancer Chemo‐Immunotherapy (Adv. Funct. Mater. 42/2017)
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2017-11-08 , DOI: 10.1002/adfm.201770248
Tomás Bauleth-Ramos _{1,

2,

3,

4} , Mohammad-Ali Shahbazi _{1,

5} , Dongfei Liu ₁ , Flavia Fontana ₁ , Alexandra Correia ₁ , Patrícia Figueiredo ₁ , Hongbo Zhang _{1,

6} , João Pedro Martins ₁ , Jouni T. Hirvonen ₁ , Pedro Granja _{2,

3,

4} , Bruno Sarmento _{2,

3,

7} , Hélder A. Santos _{1,

8}

Affiliation

The immune system can be intelligently programmed to fight cancer. In article number 1703303 by Mohammad‐Ali Shahbazi, Bruno Sarmento, Hélder A. Santos, and co‐workers, spermine‐modified acetalated dextran nanoparticles are co‐loaded with a MDM‐2 inhibitor and a cytokine for chemo‐immunotherapy. Immune cell recruitment to the cancer cells and its activation synergize the anticancer impact of the drug molecules.

中文翻译：

癌症疗法：Nutlin-3a和细胞因子共同负载精胺修饰的乙酰化葡聚糖纳米颗粒用于癌症化学免疫疗法（Adv。Funct。Mater。42/2017）

可以对免疫系统进行智能编程，以抗击癌症。在Mohammad-Ali Shahbazi，Bruno Sarmento，HélderA.Santos和同事的文章编号1703303中，将精胺修饰的缩醛化右旋糖酐纳米颗粒与MDM-2抑制剂和细胞因子共同装载用于化学免疫治疗。免疫细胞募集到癌细胞及其激活可以协同药物分子的抗癌作用。

更新日期：2017-11-08

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